|
KMID : 0624620130460080398
|
|
BMB Reports
2013 Volume.46 No. 8 p.398 ~ p.403
|
|
|
Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia
|
|
Kim Min-Jeong
Li Yong-Xin
Dewapriya Pradeep
Ryu Bo-Mi
Kim Se-Kwon
|
|
|
Abstract
|
|
|
|
Inflammatory conditions mediated by activated microglia lead to chronic neuro-degenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. This study was conducted to determine the effect of floridoside isolated from marine red algae Laurencia undulata on LPS (100 ng/ml) activated inflammatory responses in BV-2 microglia cells. The results show that floridoside has the ability to suppress pro-inflammatory responses in microglia by markedly inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Moreover, floridoside down-regulated the protein and gene expression levels of iNOS and COX-2 by significantly blocking the phosphorylation of p38 and ERK in BV-2 cells. Collectively, these results indicate that floridoside has the potential to be developed as an active agent for the treatment of neuro-inflammation.
|
|
|
KEYWORD
|
|
|
Alzheimer’s disease, Floridoside, Laurencia undulata, Neuro-inflammation, Oxidative stress
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|